Here are a few tips for walking around Toronto.
1. Look for the CN Tower. At 553m in height, you're able to see this structure just about anywhere in the city! The CN Tower is always South. That means if you can see the Tower, and you're walking towards it, you're walking south. If you're walking directly away from it, you're walking North. (This doesn't apply when you're at the waterfront as you're on the other side of the CN Tower!)
2. Downtown Toronto is built largely on a grid pattern. This means that the streets run North-South and East-West (of course, there are exceptions). This makes it easy to navigate. Yonge Street divides the city into West Toronto and East Toronto, and streets running along it will either change names in either direction (ex. College/Carlton Streets), or they will become West or East (ex. Bloor Street West, Bloor Street East)
3. Pay attention to street names. If you're on Bloor St. West, then that means you are west of Yonge Street. The same goes for if a street name has 'East' on the end. Numbers usually begin at 1 on Yonge Street and get larger the further East or West they go.
4. Become familiar with landmarks. Toronto is filled with unique-looking buildings and structures and you can use these to associate with their respective intersections. For example, the Royal Ontario Museum is at the intersection of Bloor and Avenue, and Dundas Square is at the intersection of Yonge and Dundas. You'll become familiar with these locations once you've been there.
5. If you're still lost, don't be shy to ask those around you, or ask someone in a store for directions. Torontonians are generally friendly, helpful and knowledgable.
It also doesn't hurt to bring a map!